In the SysMoore era, we are facing a lot of challenges. This talk will cover “The Five Overarching Themes” in the current IC design, including (i) PPA push, (ii) First Tapeout works, (iii) Multi-die/3D systems, (iv) Safe, secure, resilience silicon, and (v) Productivity. How Synopsys EDA uses AI/ML to cope with those challenges. 